How Long Does Lorazepam Stay in Your System?
Lorazepam is a generic name medicine for a benzodiazepine called Ativan. This medicine is useful to treat anxiety disorders, including depression and insomnia caused due to anxiety. Doctors may also prescribe it to treat irritable bowel syndrome (IBS), nausea, and vomiting caused during cancer treatment.
Lorazepam pills are also effective in treating epilepsy or seizure disorders and withdrawal symptoms caused by alcohol. There are three methods of Lorazepam administration, namely:
- Lorazepam liquid injection available only in hospital settings for emergency situation
- Lorazepam oral administration solution
- Lorazepam oral administration pills
What is Lorazepam?
Lorazepam got approval for medical use in 1977 and its generic version in 1985. As a prescription medication, Lorazepam is available as an oral administration tablet, a liquid solution consumed orally, and a Lorazepam injection in liquid form.
Doctors give Lorazepam injections only in hospital settings for emergency situations. They help treat prolonged psychosis or epileptic seizures.
Like other benzodiazepine medicines, people can also abuse Lorazepam. These medications act on the gamma-aminobutyric acid (GABA) receptors like alcohol. This is why Lorazepam helps treat alcohol withdrawal symptoms; however, it also creates similar euphoria.
People at the risk of substance abuse or who struggle with alcohol use disorder are more likely to develop Lorazepam addiction. Being a fast-acting benzodiazepine, Lorazepam tablets quickly take their effects and get rapidly metabolized out of the body.
Experts recommend taking Lorazepam for a short-term or on an “as-needed” basis. The body develops a dependence on Lorazepam medication after using it for a long time.
Lorazepam Withdrawal and Detox
Lorazepam has the potential to form dependence which leads to withdrawal symptoms when people quit it abruptly. Withdrawal from Lorazepam is more severe if the person abuses Lorazepam pills. Taking medicine at therapeutic doses is usually safe and does not have the risks of dependence and withdrawal.
Some frequent Lorazepam withdrawal symptoms include:
- Rebound insomnia
- Sleep disorders
- Aggression or intense anger
During Lorazepam detox, the body will experience symptoms from Lorazepam for 2.75 days in common. This average is affected by how long dependence on Lorazepam lasted – months versus years, for instance – and what kind of medication the person consumed. The removal half-life is average from 15.7 hours to 3.59 days. In comparison, long-performing benzodiazepines, like Valium (diazepam), can soak up to 30 days (one month) to be frequently eliminated from the body.
How long does Lorazepam stay in your system?
People using the medication often consider how long Lorazepam stays in the system. This is a significant question as multiple doses of this medicine can also lead to dependence and addiction. Additionally, taking various doses can cause Lorazepam overdose, which may be even life-threatening.
While Lorazepam is a fast-performing medicine, it has a notably longer half-life. The Lorazepam half-life is 12 hours, which means that it decreases in attention within the body through half every 12 hours.
The medicine is metabolized mainly by the liver, after which it is eliminated from the body by way of the kidneys via urine. Lorazepam can be present up to 9 days past the closing use.
Factors affecting how long Lorazepam stays in your body
There are various common factors that can affect how long Lorazepam remains in someone’s system. While prices typically comply with a reasonably regular timeline, a few humans metabolize and clear the medicine more quickly than others.
Some of the elements that could affect how long Lorazepam remains in your body include the subsequent.
Age: Older people tend to clean the medicine extra slowly than more youthful people. This is probably because older people have slower metabolisms, decreased organ characteristics, decreased blood waft, and different fitness troubles, which could affect how quickly the medicine is processed and excreted.
Kidney function: Research has observed that liver impairment does not have a good deal of an impact on Lorazepam clearance rates; however, kidney problems get associated with prolonged medicine half-life.
Height and weight: Taller, heavier humans generally clean the medicine more quickly than shorter individuals who are lightweight.
Lorazepam Dosage and Frequency of Use
Higher doses of Lorazepam take longer to metabolize. The medicine is likewise detectable for longer intervals in individuals who have been taking the medication for a longer period of time.
Use of Other Substances
The concurrent use of different substances could impact how fast every medicine gets processed and excreted from the body. For instance, eating alcohol at the same time as the usage of Lorazepam reduces clearance quotes by 18%. Researchers agree that brief-time period alcohol consumption impairs the coupling of the medicine or its metabolites, which slows the metabolism.
Lorazepam Drug Screenings
Despite being a short-acting benzodiazepine, Lorazepam remains in the body for a comparatively long duration of time. Lorazepam half-life is typically 12 hours; however, its metabolites may remain detectable in several drug tests for more than 18 hours.
Different drug screenings detect Lorazepam for different time periods. To mention, here are the most frequent Lorazepam drug tests:
- Blood test: blood can detect the presence of Lorazepam up to six hours after oral administration. However, it may detect the medicine for three days afterward. Blood tests are not common for detecting Lorazepam as urine tests are more reliable and can identify them for longer durations.
- Urine test: urine tests can detect a metabolite called Lorazepam glucuronide for up to 4.13 days after last Lorazepam use. It usually takes five to six half-lives of this medicine to get metabolized entirely out of the body. Urine tests detect Lorazepam for one to six weeks, depending upon the amount of the last dose.
- Saliva test: experts consider saliva tests to be less reliable for most medicines. Lorazepam is detectable in saliva for up to eight hours after the last administration.
- Hair test: medicines are detectable in hair strands for several months, even after you stop taking them. Additionally, the period of use also determines how long this medicine will be detectable in hair. Hair tests detect Lorazepam for four weeks.