How Long Does Klonopin Stay in your System
August 16, 2021 By David Smith 0

How Long Does Klonopin Stay in your System?

Klonopin, a brand-name medicine for Clonazepam, is often useful for issues like panic, insomnia, seizures, and alcohol withdrawal. The Klonopin medication can stay in your system for extended time periods depending upon the use and dosage. 

Even while using Klonopin medicine as prescribed, people can become dependent on it in as little as two to three weeks.

A person taking the medication may wonder how long Klonopin stays in your system. Well, it depends upon several different factors, including:

  • Dosage
  • Frequency of use
  • Duration of use
  • Metabolism
  • Genetics
  • Age
  • Weight
  • Other factors

Read on to know more about how long Klonopin stays in your body.

How long does Klonopin stay in your system?

Klonopin is a member of the benzodiazepines family that lasts for an extended time duration. In other words, it is a long-acting benzodiazepine like flurazepam, diazepam, and chlordiazepoxide.

This makes Klonopin medicine different from other short-acting benzodiazepines like triazolam and midazolam and intermediate-acting benzodiazepines like lorazepam, alprazolam, and temazepam.

However, all benzodiazepines work similarly in the brain. Experts say that they work by influencing the behavior of brain neurotransmitters GABA (gamma-aminobutyric acid). They transmit signals between the brain and nerves. So, by binding to the GABA receptors, Klonopin boosts their effectiveness to cause tranquilizing effects, reducing seizures.

People take Klonopin for anxiety, seizures, or pain in divided doses, usually taken three to four times a day. Doctors may also prescribe Klonopin for sleep issues such as insomnia. 

After taking an oral Klonopin dose, the body starts to break down the medicine right away and send it throughout the body. 

Within one to three hours, the body has peak Klonopin effects as about 90% of the medication already gets broken down by that time. At this time, Klonopin effects include:

  • Drowsiness
  • Fatigue
  • Dizziness
  • Lightheadedness
  • Inability to concentrate
  • Impaired coordination

Klonopin half-life is about 30-40 hours as it is a long-acting medicine. Yet, the effects of Klonopin last in the body for about 12 hours or so after the last oral dose. 

Due to the risks of Klonopin addiction, withdrawal symptoms are common when people try to quit cold turkey. Sometimes, Klonopin withdrawal symptoms do not appear for some days due to its longer half-life. 

How long does Klonopin stay in Lab Tests?

Klonopin pills can stay in lab tests for about 5 to 30 days depending upon several factors and the type of test conducted. However, experts find it one of the most challenging medicines to screen for due to the fact that there are more than 50 benzodiazepines, and Klonopin is one of the long-acting ones.

Despite this, many benzodiazepines get broken down into metabolites. Instead of screening for the medicine itself, lab experts often screen for the metabolites of a particular medication. However, the accuracy of these tests varies due to this. Both false positives and false negatives regularly occur with Klonopin drug tests

Klonopin is a medicine that has only one active metabolite after it gets broken down, known as 7-aminoclonazepam (7AC). This signifies that it is not easily visible on many drug tests, as indicated by SAMHSA-5. To detect this medicine, lab tests must precisely screen Klonopin or its active metabolite 7AC. 

Additionally, the accuracy of the tests also varies. For instance, some screenings for Klonopin look for Clonazepam, and only about 40% of the positive samples indicate the presence this way. When lab experts analyze for its metabolite 7AC, approximately 90% of the results are positive.

There are fundamentally four types of drug tests for detecting the presence of Klonopin. These include:

  • Saliva tests
  • Urine tests
  • Blood tests
  • Hair tests

How long does Klonopin stay in your saliva?

Klonopin half-life is about 30 hours. However, it is detectable in saliva for 5-6 days after the last dose. Saliva tests for Klonopin detecting Clonazepam are often false negatives. 7AC screenings are far more reliable to check for Klonopin.

How long does Klonopin stay in your urine?

The metabolite of Klonopin is detectable in urine for as much as 30days after the oral dose. Other screenings tested positive for 14 days or so. After 21 days, about 80% of the screenings tested positive for Klonopin.

Therefore, Klonopin stays in urine for longer than other tissues and fluids, and this testing is more reliable. Klonopin is the preferable method for detecting the presence of this medicine.

How long does Klonopin stay in your blood?

Klonopin stays in the blood for several days after last use. Due to its fast metabolic rate, it is quickly detectable in the blood samples. After breaking down to 7AC, the plasma half-life of Klonopin is up to 90 hours.

How long does Klonopin stay in your hair?

Samples of Klonopin use can stay in your hair for a couple of weeks to a month. However, metabolite tests are not reliable in the case of hair follicles. One study shows that only 60% of the people taking Klonopin tested positive. Klonopin usually remains in the hair follicles for 21-28 days. 

Factors Affecting Klonopin Duration and Elimination

Various factors affecting the duration and elimination of Klonopin include:


A massive dose of Klonopin will take extra time to do away with than a smaller Klonopin dose. The greater Klonopin inside the system at one time, the longer the drug will stay detectable in someone’s system.

Frequency and Duration of Use

With consistent use, Klonopin can build up in the body. The longer a person takes Klonopin medicine, the more likely they’re to create a tolerance to it, increasing how frequently they take medication to reap the identical consequences.

Both frequency and period of use can increase the amount of time it takes to put off Klonopin.

Metabolism or Liver Function

Because the liver is the principal organ chargeable for breaking down Klonopin, how nicely it runs or isn’t always functioning can play a giant function in how long Klonopin will stay in the body.


Being healthful and having healthy organ features approach the body can remove Klonopin from its systems. Compared to unhealthy people, who will probably suffer from slower metabolisms and less efficient organ tactics.


Generally speaking, the younger someone is, the faster they may eliminate Klonopin. This may be because of having a faster metabolism and normal health than older human beings.

However, relying on a person’s general health, age may not count as a good deal as other elements.

Weight or Body Mass Index (BMI)

Those with higher BMI, or higher percent of body fat, can also process Klonopin at a slower rate because of the medicine’s fat solubility.

The greater fat someone has, the more likely Klonopin and its metabolites will keep on with those fat cells while getting metabolized.

Taking Additional Medications

Taking more than one medicine at once can gradually slow down the liver as it has to process more than one substance simultaneously. When the body is running to process a couple of substances simultaneously, Klonopin may additionally be detectable in someone’s system longer than if you are using it as a sole medication.

These are some of the elements that could impact the amount of time it takes someone to eliminate Klonopin effects and the medicine itself. Some impacting factors may be more influential than others depending on the person and their specific circumstances.